Negative pregnancy and Rh

Negative pregnancy and Rh


- I am pregnant in week 28, I have Rh negative and my husband is positive. I am pregnant and I have not had abortions. I would like to find out if I should get a RhoGAM (TM) injection in week 28 of pregnancy to combat incompatibility. I should mention that I have no specific Rh antibodies. My gynecologist did not inform me about it. Thank you.


Depending on Rh factor (or antigen D) human red blood cells (erythrocytes) were divided into two types: those possessing antigen D or Rh factor (Rh positive) and those that did not possess this antigen (Rh negative).
In the case of a blood transfusion from a Rh positive person to a Rh negative person, anti-Rh antibodies are produced in the body of this person (because the body does not recognize the Rh factor).
Therefore it is recommended that immediately after a possible transfusion of this type to administer immunoglobulins, in this way the body no longer has to produce them alone, thus avoiding the sensitization of the body to this antigen.
Otherwise, during a second Rh positive blood transfusion, the donor's red blood cells will be agglutinated, with serious complications.

The same thing can happen when a Rh negative woman is pregnant, the child being Rh positive and at the time of birth, abortion, the baby's blood passes through the placenta into the mother's blood giving birth to the production of anti-Rh antibodies when they are not. administer from the outside.
And during the second pregnancy, these mother's antibodies combine with the red blood cells of the fetus they destroy (hemolysis), causing jaundice and severe anemia. In conclusion, administration of these immunoglobulins will be done immediately after birth.
Dr. Ciprian Pop-Began
- Obstetrics and Gynecology - Clinical Hospital of Obstetrics-Gynecology Prof. Dr. Panait Sarbu